Inovative Intensive Care Medicine

ICU cares for people who have life-threatening conditions, such as a serious injury or illness, where they receive around-the-clock monitoring and life support. A person is likely to be admitted to ICU if they are in a critical condition and need constant observation and specialised care. This can happen after major surgery, accidents, severe burn, heart or kidney failure, stroke, heart attack, pneumonia, sepsis and or if a baby is born prematurely or with a serious illness. Hydrogen gas will help all of these conditions. Urgent care and walk-in

Medical gas is critical to the function of hospitals and many other healthcare facilities. Medical gas systems in hospitals are, in a word, lifesaving. Hydrogen Piped in oxygen, nitrous oxide, nitrogen, carbon dioxide, and medical air to hospital areas such as patient rooms, recovery areas, operating rooms, and ICU departments is critical to the survival of patients and now hydrogen needs to be added to the list.

Hydrogen gas is a promising novel therapy for emergency and critical care medicine. Hydrogen gas exerts a therapeutic effect in a wide range of disease conditions: From acute illness such as ischemia–reperfusion injury, shock, and damage healing to chronic illness such as metabolic syndrome, rheumatoid arthritis, and neurodegenerative diseases. In relation to various aspects of emergency and critical care medicine we have researchers reporting hydrogen useful for acute myocardial infarction, cardiopulmonary arrest syndrome, sepsis, contrast‐induced acute kidney injury, and hemorrhagic shock. Hydrogen gas has even been used to attenuate oxidative stress in a rat model of subarachnoid hemorrhage.

This is an emergency room / ICU / Operation room hydrogen machine. Gas Production Rate: Hydrogen /Oxygen: 3000ml~6000ml/min. Hospitals and the FDA officials might not know it yet but in China is already producing hydrogen machines perfected to the climate of ICU and operating rooms.

“Critically ill patients suffer from oxidative stress caused by reactive oxygen species (ROS) and reactive nitrogen species (RNS). Although ROS/RNS are constantly produced under normal circumstances, critical illness can drastically increase their production. These patients have reduced plasma and intracellular levels of antioxidants and free electron scavengers or cofactors, and decreased activity of the enzymatic system involved in ROS detoxification. The pro-oxidant/antioxidant balance is of functional relevance during critical illness because it is involved in the pathogenesis of multiple organ failure.”[i] Hydrogen is the gas that directly and immediately addresses critical conditions resulting from massive oxidative stress.

2% hydrogen inhalation has been found affective in animal studies to be effective on acute kidney injury during septic shock. Fluid resuscitation with 2% hydrogen inhalation decreased serum creatinine, blood urea nitrogen, and neutrophil gelatinase-associated lipocalin. It also reduced oxidative stress injury and decreased renal tumor necrosis factor-α and interleukin-6 levels compared with fluid resuscitation alone. 

It has also been suggested that hydrogen-rich solution therapy may be a safe, reliable, and effective treatment for Multiple Organ Dysfunction Syndrome (MODS) induced by influenza and other viral infectious diseases.

It has recently been revealed that hydrogen can both down-regulate expression of oxidative-related genes and pro-inflammatory cytokine genes directly and indirectly. Oxidative stress and systemic inflammatory response syndrome have been confirmed to play critical roles in tissue and organ damages after polymicrobial sepsis injury, acute peritonitis injury, and peritonitis, which can develop into lethal sepsis with inappropriate treatment.

LUNG DISEASES CAUSED BY RESPIRATORY MACHINES

Administration of high concentrations of oxygen is required to maintain sufficient blood oxygenation in some critically ill patients, such as patients with acute lung injury or acute respiratory distress syndrome. However, prolonged exposure to high concentrations of oxygen results in hyperoxic lung injury, which can lead to respiratory failure. Hydrogen has been found to be an answer to this medical problem.

Hyperoxic lung injury is a major concern in critically ill patients who receive high concentrations of oxygen to treat lung diseases. Successful abrogation of hyperoxic lung injury would have a huge impact on respiratory and critical care medicine. Medical scientists have recently demonstrated that inhaled hydrogen reduced transplant-induced lung injury and induced heme oxygenase (HO)-1. Hydrogen treatment during exposure to hyperoxia significantly improved blood oxygenation, reduced inflammatory events, and induced HO-1 expression. Hydrogen gas can ameliorate hyperoxic lung injury through induction of Nrf2-dependent genes, such as HO-1.

Mechanical ventilation (MV) can provoke oxidative stress and an inflammatory response, and subsequently cause ventilator-induced lung injury (VILI), a major cause of mortality and morbidity of patients in the intensive care unit. Inhaled hydrogen can act as an antioxidant and may be useful as a novel therapeutic gas. Medical scientists have found that inhaled hydrogen gas effectively reduced VILI-associated inflammatory responses, at both a local and systemic level, via its antioxidant, anti-inflammatory and antiapoptotic effects.

The First-in-Human Pilot Study is demonstrating the safety of hydrogen gas inhalation for Post-Cardiac Arrest Syndrome. Between January 2014 and January 2015, 21 of 107 patients with out-of-hospital cardiac arrest achieved spontaneous return of circulation. No undesirable effects attributable to hydrogen were observed and 4 patients survived 90 days with a favorable neurological outcome